A unique microsphere delivery system provides therapeutic levels of antibiotic1

Microsphere technology makes ARESTIN (minocycline HCl) Microspheres, 1 mg easy to use

ARESTIN allows for easy, targeted placement at the base of the periodontal pocket.1 Once inserted in the pocket, ARESTIN microspheres immediately adhere to the surrounding surfaces, providing a sustained release of minocycline at the site of active infection.1,2

ARESTIN is easy to use1

No premixing or premeasuring

No adhesive required

No need to remove ARESTIN after treatment (since the microspheres are completely bioresorbed)

No local anesthesia required

No dressing required

ARESTIN remains active in the pocket for an extended period of time2

ARESTIN is a locally applied antibiotic that is placed directly into the infected periodontal pocket at the time of scaling and root planing (SRP).1 ARESTIN has a unique delivery system where minocycline microspheres are administered as a powder to allow for easy, targeted placement at the base of the periodontal pocket.1

  • Data suggests no significant increase of minocycline-resistant bacteria1
  • Delivers a concentrated dose directly to the base of the pocket and the active infection site1
  • Convenience of an in-office treatment with no pills to take1
  • Allows for a variable dosing, as low as 1 mg per site1

1 mg of minocycline powder per cartridge


shows how to administer
ARESTIN step by step.

Download ARESTIN Tips for Use

REFERENCES: 1. ARESTIN® (minocycline hydrochloride) Microspheres, 1 mg. Prescribing Information. OraPharma; Horsham, PA: 2015. 2. Williams RC, Paquette DW, Offenbacher S, et al. Treatment of periodontitis by local administration of minocycline microspheres: a controlled trial. J Periodontol. 2001;72(11):1535-1544.